The Causes Of Epilepsy – How The Seizures Are Triggered

The causes of epilepsy can be attributed to various factors. Seizures occur when there are fluctuations in the normal balance between neuronal excitation and inhibition in the brain. Depending upon the extent of the area of the brain that is affected, the patterns and severity levels of the seizures vary to a large extent.

causes of epilepsy
Head injuries are common causes of epilepsy in people of all age groups.

How The Causes of Epilepsy Vary With The Age Of The Individual

The causes of epilepsy differ from one individual to another based on his age. Here is an age-based classification of epilepsy causes.

1. In Babies Who Are Less Than A Month Old

  • Bleeding in the brain due to injury caused during the birth of the baby
  • Low oxygen supply to the brain during birth
  • Bacterial or viral infections in the brain
  • Defects in the development of the brain while the fetus is growing
  • Genetic reasons
  • Abnormal biochemical changes
  • Low blood sugar levels
  • Low levels of calcium or magnesium in the blood
  • The deficiency of vitamin B6

2. In Children Between 1 Month And 12 Years Of Age

  • Infection in the brain tissue
  • Traumatic injury to the brain
  • Genetic diseases such as congenital metabolic diseases
  • High grade fever between 3 months and 5 years of age (This triggers seizures called febrile seizures.)

3. In Adolescents Between 12 And 18 Years Of Age

  • A lump in the brain
  • A brain infection
  • The use of illicit drugs
  • Genetic defects in the brain

4. In Adults Between 18 And 35 Years Of Age

  • Head injuries
  • Injuries to the brain
  • Sudden abstinence from alcohol following long-term alcohol consumption
  • A lump in the brain

5. In Elderly People

  • Sudden alcohol withdrawal
  • Metabolic abnormalities
  • A high level of urea in the blood
  • Low blood sugar levels
  • Severe liver diseases
  • Abnormal levels of certain constituents of the blood

Causes Of Epilepsy – Why Seizures Occur

  • The brain is susceptible to seizures under specific conditions.

    Even normal human neuronal cells are susceptible to the factors that provoke seizures under specific conditions. But the susceptibility varies based on the severity of these factors (e.g. high grade fever in children).

    The threshold for the occurrence of seizures is determined by various parameters like genetic factors, the family’s history as far as epilepsy is concerned, or the birth of a defect during the development of brain structures.

  • A variety of conditions are responsible for long-term seizure disorders.

    Serious head injuries like penetrating trauma pose up to a 50% risk of causing long- term damage to the neural tissue. In such cases, the neurological network becomes abnormally hyper-excitable. This phenomenon is called epileptogenesis.

    Other processes like strokes, infections, neural defects, or genetic abnormalities in the brain can also trigger epileptogenesis.

  • There are certain factors that provoke seizures.

    Seizures usually occur intermittently. Individuals with epilepsy often exhibit completely normal behavior between episodes of seizures, and any routine activity may trigger a seizure episode.

    The factors that provoke seizures include:

    • Inadequate sleep
    • Exposure to flashes of light
    • Heavy alcohol consumption
    • Drug overdose (Even certain drugs of common medicinal use)
    • High stress levels
    • Hormonal changes (e.g. during menstruation)
    • Hyperventilation i.e. excessive rapid breathing
    • High grade fevers
    • Neurological infections

How Are The Seizures Triggered?

Here’s the mechanism that triggers epilepsy symptoms.

  1. Neurons (brain cells) have their own electrical potentials, set in order to maintain their optimum function. These potentials are derived from graded concentrations of various ions (sodium, calcium, potassium, etc.) both inside and outside of these cells.
  2. Under normal circumstances, these electrical potentials across the membranes of the neuronal cells are well-balanced and well-regulated. When this balance is disturbed, episodes of convulsions (seizures) are triggered by different mechanisms, depending upon the cause.
  3. Neurons of different parts of the brain control the tone and activity of the muscles of different parts of the body.
  4. Under normal conditions, excessive contractions are inhibited by opposing neurons. GABA (Gamma Amino Butyric Acid) is a neuro-chemical that inhibits further contractions of muscles via neuronal control and constantly regulates the frequency and extent of the contraction-relaxation cycles. When precipitating factors step in, this balance is disturbed and the electrical potentials across the neuronal membranes fluctuate. This causes uncontrolled, irresistible, and frequent contractions of muscles. When high-frequency bursts of electrical potential occur in localized parts of the brain, focal seizures occur.
  5. When these bursts of electrical potential are transmitted to other parts of brain, generalized tonic-clonic seizures appear.
cause of epilepsy
A lack of sleep is also a common cause of epilepsy.

Certain Other Causes Of Epilepsy

  • In the case of seizure episodes caused by infections, high grade fever, metabolic changes, poison, or trauma, the neurons become hyper-excitable and the subsequent high-frequency electrical potential bursts provoke seizures.
  • When seizures are triggered by genetic factors, the underlying reason is often the defective development of certain parts of the brain or the defective production of neuronal ion-channels. Both these factors affect neuronal excitability.

Knowing the causes of epilepsy can help you avoid or control many of the factors that trigger seizure episodes. Knowing about the types of epilepsy, its symptoms, and epilepsy treatment can help you counter this condition effectively. In fact, the best thing to do would be to take proper measures for epilepsy prevention.

Leave a Reply